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Genetic variants in APOL1 are a major contributor to the increased risk of kidney disease in people of recent African ancestry. In this session, recent insight into the contribution of the APOL1 risk genotype to different renal phenotypes will be highlighted, as well as the difficulty in determining when to when to screen and where to apply APOL1 genotype data in clinical practice. In addition, a long-lasting study showing the promise of a small-molecule inhibitor of APOL1 channel function as potential treatment will be discussed.
Ana Iltis
USA
Saraladevi Naicker
South Africa
Dwomoa Adu
Ghana
Ogo Egbuna
USA
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Contribution of APOL1 Risk Alleles to Kidney Disease in West Africa
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