The WCN’ 23 was built on three themes Kidney Failure (KF), Chronic Kidney Disease (CKD) and Acute Kidney Injury (AKI). This symposium covers eleven areas in CKD including; inflammation, diabetes, genetic diseases, novel biomarkers, new advances in RRT, glomerular disease and Epidemiology. This sessions brings latest science and broad international perspectives on CKD.
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Chronic Inflammation in the Kidney. ISN-JSN Joint Session
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Inflammation and fibrosis mediate progression of kidney disease independently of the original disease. This session will aim to cover a number of very important aspects relating to the inflammatory process in kidney disease. There will be an exploration of the understanding that we currently have regarding the molecular mechanisms involved in inflammation and fibrosis of the kidney along with potential roles of inflammatory biomarkers in kidney disease.
CKD and Diabetes: Treatment and Prevention Update
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The clinical entity of CKD and diabetes, encompasses DKD (diabetic kidney disease) and NDKD (nondiabetic kidney disease) or a combination of the two; diagnosis, disease management and research perspectives of these entities will be presented. Improved insights into the patho-mechanisms that are shared by these entities such as SGLT2 and RAASi. There will be some discussions on findings from clinical trials about new effective treatment in decreasing cardiovascular mortality and progression to end-stage renal disease. Prevention of kidney disease progression, regardless of aetiology is essential and will be discussed.
CKD and Genetic Diseases. ISN-ERA Special Lecture
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This session will aim to cover the diagnostic and therapeutic implications of using information gained through genetic testing in CKD (Chronic Kidney Disease).An overview and update on the advances made in the diagnostic use of genetic testing will be provided. There will be an exploration of the understanding of pharmacogenomics in the setting of kidney disease. Using genetic testing in a well-known example of CKD, Autosomal Dominant PKD, will allow for discussion of both the opportunities and challenges that result in a personalized approach to the care of the patient with that condition.
CKD and Novel Biomarkers
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Renal disease is the functional loss of kidneys that is represented by tissue pathology and changes in the expression of circulating molecules found in plasma and urine. These molecules can be biomarkers of present and future organ loss. In addition, some may also act as drivers (biomarkers) and therefore are directly involved in causing chronic kidney disease and disturbances of the cardiovascular system. This session will discuss key biomarker and biomarkers of chronic kidney disease, explore how large data sets aid in the diagnosis, evaluation and treatment of kidney disease and provide new mechanistic and epidemiologic insights into the dysregulated cardio-renal axis seen in chronic kidney disease. Some of the discussed molecules may inform future drug trials or have become drug targets themselves.
CKD Complications: The Latest Update
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This session will aim to cover fundamental aspects related to the understanding of the complications of chronic kidney disease (CKD) and their management. Epidemiological data describing the cardiovascular repercussions of CKD and their burden will be presented, along with specific recommendations related to their prevention and management.. Moreover, the most up-to-date advances in the field of the management of the anemia related to CKD will be showcased. There will also be an exploration of the understanding that we currently have regarding the complex pathophysiology of bone mineral disease related to CKD (CKD-BMD) and the latest advances in management. Finally, the latest evidence regarding the nutritional strategies to delay CKD progression will be explored in detail.
New Advances in RRT Technology
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For over half a century, therapy for kidney failure has consisted of either kidney dialysis or transplantation. While transplantation outcomes have significantly improved, availability of kidneys does not meet needs, thus this is a rationed resource. Hemodialysis and Peritoneal dialysis are available treatment modalities in most countries, but outcomes have not substantially improved and technology advances have been limited. This session will describe current innovations targeting improved patient outcomes, and expanded choices for therapeutic options.
New Perspectives in Glomerular Disease
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Glomerular diseases affect the filtration units of the kidney and are a common cause of renal disease and end stage renal disease. The underlying etiologies range from genetic-, to metabolic-, to toxic-, to infectious- or to immune-mediated mechanisms. The diagnosis usually involves urinary findings and histological analysis and the treatment includes causal and supportive strategies.
Perspectives in CKD Diagnostic Tools
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This session aims to introduce new CKD diagnosis using the latest state-of-art technology and its perspectives. Recent deep learning-based pathological analysis has the potential to maximize the information from small biopsy samples, and establish a more objective and quantitative diagnosis. In addition, multiplex tissue imaging can visualize various cellular phenotypes and cell-cell interactions in situ in biopsy samples. These newest technologies have the potential to take pathological diagnosis to a new dimension.
Toward Excellence in Peritoneal Dialysis Care
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Peritoneal Dialysis is a well-established treatment modality, providing similar survival outcomes to hemodialysis, while increasing patient autonomy. This session will describe best practices at the patient level and at the programmatic (systems) level, especially in low and low-middle income countries.
Update on CKD Epidemiology. ISN-KSN Joint Session
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This session will provide a comprehensive overview of the epidemiology of chronic kidney disease, with specific focus on the incidence, prevalence and risk factors of CKD in LIC and LMIC. Knowledge of the predictor factors of CKDu will also be presented. Epidemiological data describing the disparities in access and outcomes by gender, race, ethnicity and socioeconomic status will be explored. A review of current and novel therapeutic strategies for the prevention of CKD progression and management of advance stage CKD will be discussed.
What Drives AKI toward CKD Progression?
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This session will aim to cover a number of very important aspects relating to the driving process/forces behind the AKI-to-CKD progression. Our current understanding of the pathophysiological changes occurring in those who suffer from AKI will be presented, including subsequent development of chronic kidney disease. We will explore current understanding of molecular mechanisms involved in the recovery process. The important question of whether we can halt the development of chronic kidney disease following kidney injury will be discussed with a review of current and novel therapeutic strategies.
Learning Objectives:
An appreciation of the pathophysiological changes associated with acute kidney injury. An increased understanding of the molecular mechanisms involved in the recovery process following acute kidney injury. An increased awareness of possible therapeutic strategies to prevent the development of chronic kidney disease following acute kidney injury