Preparatory webinar series for the WCN'26 Course: "Tools to Strengthen Global Kidney Trials: Design, Innovative Endpoints, and Communication Across Regions"
Recorded On: 02/26/2026
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Participants must have attended or watch the on-demand recordings of the two preparatory webinar sessions to fully engage with the course content.
ISN Webinar: Innovative trial designs and generalizability in clinical research
This webinar is a preparatory module for the Clinical Trials Pre-Course at WCN’26. This webinar will address two main areas of discussion: novel trial designs and generalizability. Sub-topics will include issues related to sex, gender, age, and what we can learn from those different groups. Challenges and needs in pediatric nephrology will also be discussed.
Learning objectives:
- To gain an understanding of the value of different trial designs to answer important questions.
- To gain an understanding of issues related including people across the age, sex, gender, ethnicity spectrum, and the value of inclusivity in interpreting clinical trials.
- To understand the specific challenges of studies in pediatric populations, and ways to overcome them.
ISN Webinar: Endpoint selection and statistical considerations for Innovative Trials
This webinar is a preparatory module for the Clinical Trials Pre-Course at WCN’26. This webinar will address outcome selection and analysis for innovative clinical trials focusing on Patient Reported Outcomes (PROMS), composite and hierarchical outcomes. Subthemes will include how to select the right PROMs, considering relevance, validity and ceiling effect and floor effect. The advantages and challenges of selecting and analysing composite and hierarchical outcomes will be discussed including important statistical methods such as win ratio.
Learning objectives:
- To gain an understanding of the value, selection and analysis of PROMs in clinical trials.
- To gain an understanding of the value of composite and hierarchical endpoints to increase efficiency and relevance of clinical trials.
- To understand the specific statistical approaches of hierarchical endpoints+
Further reading:
ISN Webinar: Innovative trial designs and generalizability in clinical research
- Development and validation of a new hierarchical composite end point for clinical trials of kidney disease progression
- Validity and Utility of a Hierarchical Composite End Point for Clinical Trials of Kidney Disease Progression: A Review
- A Hierarchical Composite Endpoint for Chronic Kidney Disease Progression in Patients with Focal Segmental Glomerulosclerosis
- Use of eGFR Slope Thresholds as End Point Components in a Kidney Disease Progression Hierarchical Composite End Point
Adeera Levin
Canada
Andrea Viecelli
Australia
A/Prof Andrea Viecelli is an academic nephrologist at Princess Alexandra Hospital and was awarded her PhD in 2019 through the University of Queensland. As a clinical trialist of the Australasian Kidney Trials Network (AKTN) she plays a key role in designing and conducting international clinical trials in people with chronic kidney disease. As a Coordinating Committee member and Vascular Access Project Coordinator of the global SONG initiative, she is conducting clinical and qualitative research to establish standardised core outcome measures based on the shared priorities of patients, clinicians, researchers and policy makers from >100 countries to improve the relevance and reliability of kidney research to inform patient-centred care. As the recipient of a National Health and Medical Research Council (NHMRC) Emerging Leadership Investigator Grant and a Queensland Advancing Clinical Research Fellowship she currently pursues a program of clinical research to improve patient-important outcomes in haemodialysis.
Arpana Iyengar
India
Brendan Smyth
Australia
Jennifer Lees
UK
Megumi Oshima
Japan
Martin Howell
Australia
Niels Jongs
Netherlands
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