
Grand Rounds in Pediatric Nephrology
Recorded On: 05/03/2021
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- A tale of two pathologies: Rapidly Progressive Glomerulonephritis and Acute Tubulointerstitial Nephritis
- Nephropathic Cystinosis: How to Diagnose and Treat
- Make the Peritoneal Membrane Work for You
- Approach to Infantile Hypercalcemia
- Pediatric Renal Genetics: New Advances
- Management of Renal Bone Disease
- Resistant Hypertension in Children on Dialysis
- C3 Glomerulonephritis and Dense Deposit Disease – A Tale of Two Twins
- Immunosuppression vs post-transplant viral infections: Walking a fine line
- A Challenging Case of Nephrotic Syndrome
- The Spectrum of Alport Syndrome: Who and how to investigate?

Rukshana Shroff
UK

Neha Bhongale
India

Jyoti Sharma
India

John Mahan
USA

Sukanya Govindan
India

Oluseyi Oniyangi
Nigeria

Gabriel Obiorah Ezeh
Nigeria

Shaegan Irusen
South Africa

Priya Pais
India

Soumya Reddy
India

Paul Goodyer
Canada

Elena Levtchenko
Belgium

Larisa Prikhodina
Russia

Svetlana Papizh
Russia

Felicia Eke
Nigeria

Ifeoma Anochie
Nigeria

Frederick Kaskel
USA

James Pullman
USA

Kimberly Reidy
USA

Nicole Hayde
USA

Pooja G N
India

Marcelo Orias
USA

Indira Agarwal
India

Rouba Garro
USA

Naorem Lakshmee Devi
India

Sukanya Govindan (Moderator)
India

Nadira Sultana
Bangladesh

Ng Kar Hui
Singapore

Syed Saimul Huque
Bangladesh

Fiona Mackie (Moderator)
Australia

Rajiv Sinha
India

Sanjukta Poddar
India

Mordi Mourah
UK

Asheeta Gupta
UK

Alexey N. Tsygin
Russia

Komiljon Khamzaev
Uzbekistan

Fayzakhmatova Feruza
Uzbekistan
Key:





Approach to Treating Lupus Nephritis in Children
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Open to view video.
Kidney involvement is common in lupus and the prognosis depends upon the underlying pathology and optimal and early immunosuppressive treatment. The approach should be based on kidney biopsy data, kidney function and immune tests. Different immunosuppressive regimens are indicated in pathology classes III to V based on steroids, cyclophosphamide, MMF and AZA. Monoclonal antibodies as Rituximab and Belimumab are extensively used in the last decades. The results of clinical trials and guidelines will be discussed.
C3 Glomerulonephritis and Dense Deposit Disease – A Tale of Two Twins
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Open to view video.
C3 glomerulopathy is defined by the Consensus Group 2013 as a rare group of kidney disorders due to complement dysregulation. The single diagnostic criteria is dominant C3 deposition in kidney with clinical features of glomerulonephritis (GN). It includes both Dense Deposit Disease (DDD) and C3 GN which have overlapping clinicopathological features. Electron microscopy is necessary to distinguish both. Investigations include tests for complements, antibodies to complement regulating proteins, C3 NeF and genetic analysis. 70% of children and 30 to 50% of adults reach ESKD in 10 years. No treatment is universally effective, though immunosuppression may help.
A tale of two pathologies: Rapidly Progressive Glomerulonephritis and Acute Tubulointerstitial Nephritis
Open to view video.
Open to view video.
Immunosuppression vs post-transplant viral infections: Walking a fine line
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Open to view video.
BK virus (BKV) is a common infection after kidney transplant (KT), with rising prevalence in the era of more potent immunosuppression. Uncontrolled, BKV infection can lead to BK-associated nephropathy, irreversible damage, and graft loss. Concurrent BKV nephropathy and acute rejection is not uncommon, and treatment is challenging. We discuss the case of a child who presented three years after living donor KT with fever, weight loss, GI symptoms, and acute graft dysfunction. Virology screen revealed CMV, BKV, and EBV viremia. Kidney biopsy showed acute cellular rejection. Optimized immunosuppression and antiviral therapy resulted in resolution of viremia and nearly baseline creatinine.
A Challenging Case of Nephrotic Syndrome
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Open to view video.
Nephrotic syndrome refractory to standard treatment poses a challenging problem to paediatric nephrologists. Management issues involve many inter-dependent factors, including fluid status, kidney function, nutrition, infection and thrombosis risks. We will present a case of a child with primary nephrotic syndrome refractory to standard treatment. This session will address common management challenges of a nephrotic child, immunosuppressive strategies and general approach to genetic testing.
The Spectrum of Alport Syndrome: Who and how to investigate?
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Open to view video.
Early diagnosis and pharmacologic intervention can delay progression of chronic kidney disease and the onset of kidney failure in patients with Alport syndrome. We aim to highlight the phenotypic spectrum of this condition through a series of cases. We will cover key updates in diagnostics with a focus on genomics, as well as longer term surveillance and management of patients with Alport syndrome.
Renal amyloidosis presenting as glucocorticoid resistant nephrotic syndrome
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Open to view video.
Amyloidosis is a rare multi-system disease. In children, amyloid A (AA) amyloidosis (previously known as reactive or secondary amyloidosis) may occur due to chronic inflammation. Pediatric AA amyloidosis mainly involves the kidneys and presents with proteinuria, hematuria, hypertension and nephrotic syndrome. Therapy for AA amyloidosis is targeted towards control of the underlying inflammatory disease and suppression of serum amyloid protein production.
In this webinar, we will present a case of renal amyloidosis, successfully treated with IL-6 antibody.