Grand Rounds in Pediatric Nephrology

Recorded On: 05/03/2021

  1. A tale of two pathologies: Rapidly Progressive Glomerulonephritis and Acute Tubulointerstitial Nephritis
  2. Nephropathic Cystinosis: How to Diagnose and Treat
  3. Make the Peritoneal Membrane Work for You
  4. Approach to Infantile Hypercalcemia
  5. Pediatric Renal Genetics: New Advances 
  6. Management of Renal Bone Disease
  7. Resistant Hypertension in Children on Dialysis 
  8. C3 Glomerulonephritis and Dense Deposit Disease – A Tale of Two Twins
  9. Immunosuppression vs post-transplant viral infections: Walking a fine line
  10. The Spectrum of Alport Syndrome: Who and how to investigate?

Rukshana Shroff

UK

Neha Bhongale

India

Jyoti Sharma

India

John Mahan

USA

Sukanya Govindan

India

Oluseyi Oniyangi

Nigeria

Gabriel Obiorah Ezeh

Nigeria

Shaegan Irusen

South Africa

Priya Pais

India

Soumya Reddy

India

Paul Goodyer

Canada

Elena Levtchenko

Belgium

Larisa Prikhodina

Russia

Svetlana Papizh

Russia

Felicia Eke

Nigeria

Ifeoma Anochie

Nigeria

Frederick Kaskel

USA

James Pullman

USA

Kimberly Reidy

USA

Nicole Hayde

USA

Pooja G N

India

Marcelo Orias

USA

Indira Agarwal

India

Rouba Garro

USA

Naorem Lakshmee Devi

India

Sukanya Govindan (Moderator)

India

Nadira Sultana

Bangladesh

Ng Kar Hui

Singapore

Syed Saimul Huque

Bangladesh

Fiona Mackie (Moderator)

Australia

Rajiv Sinha

India

Sanjukta Poddar

India

Mordi Mourah

UK

Asheeta Gupta

UK

Key:

Complete
Failed
Available
Locked
C3 Glomerulonephritis and Dense Deposit Disease – A Tale of Two Twins
Open to view video.
Open to view video. C3 glomerulopathy is defined by the Consensus Group 2013 as a rare group of kidney disorders due to complement dysregulation. The single diagnostic criteria is dominant C3 deposition in kidney with clinical features of glomerulonephritis (GN). It includes both Dense Deposit Disease (DDD) and C3 GN which have overlapping clinicopathological features. Electron microscopy is necessary to distinguish both. Investigations include tests for complements, antibodies to complement regulating proteins, C3 NeF and genetic analysis. 70% of children and 30 to 50% of adults reach ESKD in 10 years. No treatment is universally effective, though immunosuppression may help.
Resistant Hypertension in Children on Dialysis
Open to view video.
Open to view video.
Management of Renal Bone Disease
Open to view video.
Open to view video.
Pediatric Renal Genetics: New Advances
Open to view video.
Open to view video.
Nephropathic Cystinosis: How to Diagnose and Treat
Open to view video.
Open to view video.
Approach to Infantile Hypercalcemia
Open to view video.
Open to view video.
A tale of two pathologies: Rapidly Progressive Glomerulonephritis and Acute Tubulointerstitial Nephritis
Open to view video.
Open to view video.
Make the Peritoneal Membrane Work for You
Open to view video.
Open to view video.
Immunosuppression vs post-transplant viral infections: Walking a fine line
Open to view video.
Open to view video. BK virus (BKV) is a common infection after kidney transplant (KT), with rising prevalence in the era of more potent immunosuppression. Uncontrolled, BKV infection can lead to BK-associated nephropathy, irreversible damage, and graft loss. Concurrent BKV nephropathy and acute rejection is not uncommon, and treatment is challenging. We discuss the case of a child who presented three years after living donor KT with fever, weight loss, GI symptoms, and acute graft dysfunction. Virology screen revealed CMV, BKV, and EBV viremia. Kidney biopsy showed acute cellular rejection. Optimized immunosuppression and antiviral therapy resulted in resolution of viremia and nearly baseline creatinine.
A Challenging Case of Nephrotic Syndrome
Open to view video.
Open to view video. Nephrotic syndrome refractory to standard treatment poses a challenging problem to paediatric nephrologists. Management issues involve many inter-dependent factors, including fluid status, kidney function, nutrition, infection and thrombosis risks. We will present a case of a child with primary nephrotic syndrome refractory to standard treatment. This session will address common management challenges of a nephrotic child, immunosuppressive strategies and general approach to genetic testing.
The Spectrum of Alport Syndrome: Who and how to investigate?
Open to view video.
Open to view video. Early diagnosis and pharmacologic intervention can delay progression of chronic kidney disease and the onset of kidney failure in patients with Alport syndrome. We aim to highlight the phenotypic spectrum of this condition through a series of cases. We will cover key updates in diagnostics with a focus on genomics, as well as longer term surveillance and management of patients with Alport syndrome.