ISN-UKKA Webinar: Dialysis or conservative kidney management for kidney failure – the first results of the Prepare for Kidney Care randomized controlled trial

Prepare for Kidney Care is the first randomized controlled trial comparing preparation for dialysis with conservative kidney management in older people approaching kidney failure.

While a combination of quality and length of life formed the primary outcome, many other outcomes relevant for shared informed decision making have been studied.

Prepare for Kidney Care was conducted across 31 kidney units in the UK, recruiting 445 participants who were then followed for an average of 4.5 years. This webinar will begin by setting out what is already known about this topic, before moving on to explain the design and present the results and conclusions. An expert patient and independent expert health professional will then reflect on the findings. Finally, there will be an opportunity for webinar attendees to put questions to the panel.

Learning objectives:

 -To understand what is currently known about the effectiveness of dialysis and conservative kidney management in older people living with kidney failure and multimorbidity or frailty.
- To learn whether/ how the relative effectiveness of the treatments changes when a randomised controlled trial approach is used to ensure a fair comparison between the two treatments.
- To understand when, and in whom, the findings can be used in shared informed decision making, and when, and in whom, they might need to be used more cautiously.

Further reading:

• The Prepare for Kidney Care Study: prepare for renal dialysis versus responsive management in advanced chronic kidney disease
• Preparing for responsive management versus preparing for renal dialysis in multimorbid older people with advanced chronic kidney disease (Prepare for Kidney Care): Study protocol for a randomised controlled trial
• Kidney Health Guidance on Conservative Management Practical guidance for US practice doi.org/10.1681/ASN.0000001068
• Conservative kidney management and kidney supportive care Definitions and core components https://www.kidney-internation...  
• Kidney Supportive Care and Conservative Kidney Management Curriculum Free online course with CME https://academy.theisn.org/pro...  
• Preparing for responsive management versus renal dialysis in older people living with kidney failure and frailty or multimorbidity in the UK (Prepare for Kidney Care): a two-arm, superiority, parallel-group, open-label, pragmatic, phase 3, individually randomised controlled trial https://www.sciencedirect.com/...   
• Treatment options for older people with kidney failure: the Prepare for Kidney Care study results