ISN-ISE Webinar: The Gut-Kidney-Endocrine Axis: Microbiome, Metabolism, and Kidney Crosstalk

The human microbiome is a critical modulator of systemic health, influencing metabolic pathways, hormonal signaling, and kidney function. Increasing evidence highlights a complex axis connecting the gut, kidneys, and endocrine system, in which dysbiosis contributes to metabolic syndrome, diabetes, and chronic kidney disease (CKD). This webinar will bring together leading experts in nephrology and endocrinology to explore the latest insights into this axis. We will cover mechanisms, clinical implications, and therapeutic strategies—including the impact of GLP-1 receptor agonists, SGLT2 inhibitors, and microbiome-targeted interventions. Join us as we unpack this intricate network and its relevance to everyday clinical practice.

Learning objectives: 

Describe the bidirectional interactions between the gut microbiome, kidneys, and endocrine/metabolic system.Explain how gut dysbiosis contributes to metabolic disorders and CKD progression.
Discuss hormonal pathways influenced by the microbiome and their impact on renal and metabolic health.
Explore clinical and therapeutic implications of targeting the gut-kidney-endocrine axis.

Further reading:

Vaziri ND, et al. Chronic kidney disease alters intestinal microbial flora. Kidney Int. 2013;83(2):308–15.
WL Lau, T Tran, CM Rhee, K Kalantar-Zadeh, ND Vaziri. Diabetes and the gut microbiome. Seminars in nephrology 41(2),104-113.
Helen L. MacLaughlin, Allon N. Friedman, and T. Alp Ikizler. Nutrition in Kidney Disease: Core Curriculum 2022. AJKD 79(3):437-449, 2022.
Wu IW, et al. Gut microbiota as diagnostic tools for mirroring disease progression and activity in chronic kidney disease: Discovery and validation study. Int J Biol Sci. 2020;16(3):420–428.
Cani PD, et al. The role of the gut microbiota in energy metabolism and metabolic disease. Curr Pharm Des. 2009;15(13):1546–1558.