ISN Global Trials Focus: January 2020
ISN Academy. ISN-ACT . 01/21/20; 287969; 6175 Topic: Global Nephrology
Disclosure(s)(s): The ISN-Advancing Clinical Trials is a new initiative of the ISN intended to leverage existing infrastructures within ISN, in order to improve global nephrology community participation in clinical trial research. As part of its activities, the ISN-ACT highlights and sometimes analyzes important recent nephrology trials from latest medical literature every month through the ISN-ACT Trial-list. Editors of the ISN-ACT Trial-List also select clinical trials of particular impact, and collaborate with the @ISNeducation social media learning team to represent these trials visually. Join the ISN-ACT To generate more high-quality clinical trials and studies in nephrology, ISN-ACT is calling on investigators and interested individuals. If you are an ISN member interested to join this great initiative, submit your application online. Use the button below (download PDF) to download this month's edition of the list.
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The ISN-ACT (Advancing Clinical Trials) team presents this monthly showcase of randomized trials in nephrology from around the world. The trials selected are not necessarily those likely to have the highest impact. Our aim is to showcase the diversity of trials recently published and to review these in context, assessing their risk of bias in seven key areas. We hope that our efforts will drive improvement in trial quality and promote greater engagement in trial activity.

Join the debate in the Discussion Forum: Will these trials affect your practice? Are the results valid? How could the trials have been improved? What further studies are needed? Click on the Discussion Forum button above and start interacting!

This month, we reviewed the following trials:

- Brace for it: an external support device may help fistulas to mature
An Implanted Blood Vessel Support Device for Arteriovenous Fistulas: A Randomized Controlled Trial Karydis et al. Am J Kidney Dis. 2020;75(1):45-53

- No benefit from routine bioimpedence spectroscopy in PD
Bioimpedance spectroscopy-guided fluid management in peritoneal dialysis patients with residual kidney function: A randomized controlled trial
Yoon et al. Nephology. 2019;24(12):1279–1289

- Novel kappa opioid receptor agonist improves itch in people receiving hemodialysis therapy
A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus Fishbane et al. N Engl J Med. 2019 Nov 8. doi: 10.1056/NEJMoa1912770.

- Thinking zinc? Not all replacement formulations are equal
Comparison of zinc acetate hydrate and polaprezinc for zinc deficiency in patients on maintenance hemodialysis: A single-center, open-label, prospective randomized study
Ther Apher Dial. 2019 Dec 3. doi: 10.1111/1744-9987.13461

- Getting things straight when it comes to peritoneal dialysis catheters
Straight Versus Coiled Peritoneal Dialysis Catheters: A Randomized Controlled Trial.
Am J Kidney Dis. 2020;75(1):39-44

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