ISN Global Trials Focus: November 2019
ISN Academy. ISN-ACT . 11/18/19; 286679; 6175 Topic: Global Nephrology
Disclosure(s)(s): The ISN-Advancing Clinical Trials is a new initiative of the ISN intended to leverage existing infrastructures within ISN, in order to improve global nephrology community participation in clinical trial research. As part of its activities, the ISN-ACT highlights and sometimes analyzes important recent nephrology trials from latest medical literature every month through the ISN-ACT Trial-list. Editors of the ISN-ACT Trial-List also select clinical trials of particular impact, and collaborate with the @ISNeducation social media learning team to represent these trials visually. Join the ISN-ACT To generate more high-quality clinical trials and studies in nephrology, ISN-ACT is calling on investigators and interested individuals. If you are an ISN member interested to join this great initiative, submit your application online. Use the button below (download PDF) to download this month's edition of the list.
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The ISN-ACT (Advancing Clinical Trials) team presents this monthly showcase of randomized trials in nephrology from around the world. The trials selected are not necessarily those likely to have the highest impact. Our aim is to showcase the diversity of trials recently published and to review these in context, assessing their risk of bias in seven key areas. We hope that our efforts will drive improvement in trial quality and promote greater engagement in trial activity.

Join the debate in the Discussion Forum: Will these trials affect your practice? Are the results valid? How could the trials have been improved? What further studies are needed? Click on the Discussion Forum button above and start interacting!

This month, we reviewed the following trials:

- Isometric handgrip exercises improve cephalic vein diameter in Malaysian patients with CKD stage 3 to 4 Effect of isometric handgrip exercise on the size of cephalic veins in patients with stage 3 and 4 chronic kidney disease: A randomized controlled trial. Kumar et al. J Vasc Access. 2019 Oct 4:1129729819879314

- Still waiting for evidence to determine the effect of vitamin K on calcification in haemodialysis patients
The effect of vitamin K2 supplementation on vascular calcification in haemodialysis patients: a 1 year follow up randomized trial
Oikonomaki et al. Int Urol Nephrol. 2019;51(11):2037–2044

- Patiromer a promising potassium binder for those needing to stay on spironolactone
Patiromer versus placebo to enable spironolactone use in patients with resistant hypertension and chronic kidney disease (AMBER): a phase 2, randomised, double-blind, placebo-controlled trial
Agarwal et al. Lancet. 2019;394(10208):1540-1550

-Is ASK an answer? ASK1 inhibitor may slow progression of diabetic kidney disease
Effects of selonsertib in patients with diabetic kidney disease
Chertow et al. J Am Soc Nephrol. 2019;30(10):1980-1990

- Everolimus vs. cyclosporine for older recipients of older donor kidneys: many questions remain
Everolimus in de novo kidney transplant recipients participating in the Eurotransplant senior program: Results of a prospective randomized multicenter study (SENATOR)
Brakemeier et al. PLoS One. 2019;14(9):e0222730

- Mid-cut off membranes do increase middle-weight molecule clearance
Comparison of the removal of uraemic toxins with medium cut-off and high-flux dialysers: a randomized clinical trial
Belmouaz Nephrol Dial Transplant. 2019 Oct 3. pii: gfz189. doi: 10.1093/ndt/gfz189

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