ISN Global Trials Focus: October 2019
ISN Academy. ISN-ACT . 10/08/19; 284462; 6175 Topic: Global Nephrology
Disclosure(s)(s): The ISN-Advancing Clinical Trials is a new initiative of the ISN intended to leverage existing infrastructures within ISN, in order to improve global nephrology community participation in clinical trial research. As part of its activities, the ISN-ACT highlights and sometimes analyzes important recent nephrology trials from latest medical literature every month through the ISN-ACT Trial-list. Editors of the ISN-ACT Trial-List also select clinical trials of particular impact, and collaborate with the @ISNeducation social media learning team to represent these trials visually. Join the ISN-ACT To generate more high-quality clinical trials and studies in nephrology, ISN-ACT is calling on investigators and interested individuals. If you are an ISN member interested to join this great initiative, submit your application online. Use the button below (download PDF) to download this month's edition of the list.
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The ISN-ACT (Advancing Clinical Trials) team presents this monthly showcase of randomized trials in nephrology from around the world. The trials selected are not necessarily those likely to have the highest impact. Our aim is to showcase the diversity of trials recently published and to review these in context, assessing their risk of bias in seven key areas. We hope that our efforts will drive improvement in trial quality and promote greater engagement in trial activity.

Join the debate in the Discussion Forum: Will these trials affect your practice? Are the results valid? How could the trials have been improved? What further studies are needed?

You can access the forum on this page, clicking on the Discussion Forum button above.

Please make sure to come back often to follow the forum discussion.

This month, we reviewed the following trials:

- Sodium zirconium cyclosilicate is an effective treatment for hyperkalemia in hemodialysis patients
A Phase 3b, Randomized, Double-Blind, Placebo-Controlled Study of Sodium Zirconium Cyclosilicate for Reducing the Incidence of Predialysis Hyperkalemia (DIALIZE study)
Fishbane et al. J Am Soc Nephrol. 2019;30(9):1723-1733

- Vitamin C and hemodialysis AV access restenosis: pilot study hints at promise
A randomized feasibility study of the effect of ascorbic acid on post-angioplasty restenosis of hemodialysis vascular access
Yang et al. Sci Rep. 2019 Jul 31;9(1):11095

- A more palatable alternative for preventing renal calculi?
Lime powder regimen supplement alleviates urinary metabolic abnormalities in urolithiasis patients
Ungjaroenwathana et al. Nephrology (Carlton). 2019 Aug;24(8):791-797

- A multifaceted personal systems approach can improve medication adherence in adult kidney transplant recipients for up to 1 year
Improving medication adherence and outcomes in adult kidney transplant patients using a personal systems approach SystemCHANGETM results of the MAGIC randomized clinical trial
Russell et al. Am J Transplant. 2019. doi: 10.1111/ajt.15528

- No benefit from peritoneal lavage in severe PD peritonitis
Randomized controlled trial on adjunctive lavage for severe peritonitis
Wong et al. Perit Dial Int. 2019 Sep-Oct;39(5):447-454

- Bexagliflozin is effective in Type 2 Diabetics with CKD stage 3
Safety and Effectiveness of Bexagliflozin in Patients With Type 2 Diabetes Mellitus and Stage 3a/3b CKD
Allegretti et al. Am J Kidney Dis. 2019;74(3): 328-337

- Lower viral infections and similar graft outcomes with everolimus in majority African-American kidney transplant cohort
Randomized controlled trial assessing the impact of everolimus and low-exposure tacrolimus on graft outcomes in kidney transplant recipients
Taber et al. Clin Transplant. 2019 Jul 31:e13679

- Multidisciplinary and holistic approach proves a winner in Chinese PD patients
Effects of Multidisciplinary Team Care Based on 5E’s Renal Rehabilitation for Peritoneal Dialysis Patients in Guangxi Zhuang Autonomous Region of China: A Randomized Controlled Trial
Luo et al. Blood Purif. 2019;48(2):115-123

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