ISN-ACT Clinical Trial List: November 2018
ISN Academy. ISN-ACT . Dec 10, 2018; 234811
Topic: General Nephrology
Disclosure(s): The ISN-Advancing Clinical Trials is a new initiative of the ISN intended to leverage existing infrastructures within ISN, in order to improve global nephrology community participation in clinical trial research. As part of its activities, the ISN-ACT highlights and sometimes analyzes important recent nephrology trials from latest medical literature every month through the ISN-ACT Trial-list. Editors of the ISN-ACT Trial-List also select clinical trials of particular impact, and collaborate with the @ISNeducation social media learning team to represent these trials visually. Join the ISN-ACT To generate more high-quality clinical trials and studies in nephrology, ISN-ACT is calling on investigators and interested individuals. If you are an ISN member interested to join this great initiative, submit your application online. Use the button below (download PDF) to download this month's edition of the list.
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Once a month, the ISN-ACT (Advancing Clinical Trials) team collects and publishes a list of important nephrology trials from the latest medical literature. Each trial is reviewed in context and their risk of bias in seven key areas assessed. This month, we reviewed the following trials:

- What’s the hurry? No benefit to early RRT in sepsis
Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis
Barbar, et al. N Eng J Med. 2018;379(15):1431-1442

- High cut off membranes no better than standard membranes in patients requiring hemofiltration for AKI and shock
A Double-Blind Randomized Controlled Trial of High Cutoff Versus Standard Hemofiltration in Critically Ill Patients With Acute Kidney Injury
Atan, et al. Crit Care Med. 2018 Oct;46(10):e988-e994. doi: 10.1097/CCM.0000000000003350

- Alkali therapy may affect vascular function in CKD
Effect of treatment of metabolic acidosis on vascular endothelial function in patients with CKD
Kendrick, et al. Clin J Am Soc Nephrol. 2018;13(10):1463-1470

- Novel locking cocktail of trimethoprim, EDTA and ethanol may reduce dialysis catheter related infections
Locking hemodialysis catheters with Trimethoprim-Ethanol-Ca-EDTA to prevent bloodstream infections. A randomized, evaluator blinded clinical trial
Rijnders, et al. Clin Infect Dis. 2018 Oct 3. doi: 10.1093/cid/ciy840

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