ISN-ACT Trial List: October 2018
ISN Academy. ISN-ACT . Oct 9, 2018; 233833
Topic: General Nephrology
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Once a month, the ISN-ACT (Advancing Clinical Trials) team collects and publishes a list of important nephrology trials from the latest medical literature. Each trial is reviewed in context and their risk of bias in seven key areas assessed. This month, we reviewed the following trials:

- Febuxostat does not slow decline in renal function in Japanese RCT
Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial
Am J Kidney Dis. 2018 Aug 31. pii: S0272-6386(18)30834-5

- Are two jabs better than one for transplant recipients?
Immunogenicity and safety of double versus standard dose of the seasonal influenza vaccine in solid-organ transplant recipients: A randomized controlled trial
Mombelli, et al. Vaccine. 2018;36(41):6163-6169

- Small study raises question mark over drug-coated balloon angioplasty in AVF
Drug-Coated Versus Plain Balloon Angioplasty In Arteriovenous Fistulas: A Randomized, Controlled Study With 1-Year Follow-Up (The Drecorest Ii-Study)
Björkman, et al. Scand J Surg. 2018 Sep 5:1457496918798206

- Calcium channel blockers may have an edge over thiazides and ACE inhibitors in essential hypertension in Ethiopia
Comparative effectiveness of antihypertensive drugs prescribed in Ethiopian healthcare practice: A pilot prospective, randomized, open label study
Mengesha, et al. PLoS One. 2018;13(9):e0203166

- More evidence in favour of rising tide of peritoneal dialysis in the ICU
Acute Kidney Injury in Critically Ill Patients: A Prospective Randomized Study of Tidal Peritoneal Dialysis Versus Continuous Renal Replacement Therapy
Al-Hwiesh, et al. Ther Apher Dial 2018;22(4):371–379

- Higher dialysate magnesium lowers serum calcification propensity
The Effect of Increasing Dialysate Magnesium on Serum Calcification Propensity in Subjects with End Stage Kidney Disease: A Randomized, Controlled Clinical Trial
Bressendorff, et al. Clin J Am Soc Nephrol. 2018;13(9):1373-1380

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