ISN-ACT Trial List: July 2018
ISN Academy. ISN-ACT . Jul 12, 2018; 224085
Topic: General Nephrology
Disclosure(s): The ISN-Advancing Clinical Trials is a new initiative of the ISN intended to leverage existing infrastructures within ISN, in order to improve global nephrology community participation in clinical trial research. As part of its activities, the ISN-ACT highlights and sometimes analyzes important recent nephrology trials from latest medical literature every month through the ISN-ACT Trial-list. Editors of the ISN-ACT Trial-List also select clinical trials of particular impact, and collaborate with the @ISNeducation social media learning team to represent these trials visually. Join the ISN-ACT To generate more high-quality clinical trials and studies in nephrology, ISN-ACT is calling on investigators and interested individuals. If you are an ISN member interested to join this great initiative, submit your application online. Use the button below (download PDF) to download this month's edition of the list.
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Once a month, the ISN-ACT (Advancing Clinical Trials) team collects and publishes a list of important nephrology trials from the latest medical literature. Each trial is reviewed in context and their risk of bias in seven key areas assessed. This month, we reviewed the following trials: - Smartphone app improves self-reported medication adherence but does not lead to lower blood pressure Association of a Smartphone Application With Medication Adherence and Blood Pressure Control: The MedISAFE-BP Randomized Clinical Trial Morawski, et al. JAMA Intern Med. 2018;178(6):802-09 - Family consultation does not reduce readmission rates in small single-centre study of hospitalized patients with ESKD Family Consultation to Reduce Early Hospital Readmissions among Patients with End Stage Kidney Disease: A Randomized Controlled Trial Jasinsky, et al. Clin J Am Soc Nephrol.2018;13(6):850-57 - Renal denervation lowers blood pressure when antihypertensive agent regimens are held constant Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial Kandzari, et al. Lancet. 2018;391(10137):2346-55 - Pilot study shows endovascular ultrasound is a feasible means of renal denervation Endovascular ultrasound renal denervation to treat hypertension (RADIANCE-HTN SOLO): a multicentre, international, single-blind, randomised, sham-controlled trial Azizi, et al. Lancet. 2018;391(10137):2335-45 - Could magnesium supplementation be a simple antidote to the metabolic syndrome? Oral Magnesium Supplementation and Metabolic Syndrome: A Randomized Double-Blind Placebo-Controlled Clinical Trial Rodríguez-Morán, et al. Adv Chronic Kidney Dis. 2018;25(3):261-266

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